Space
From Memory Alpha, the free Star Trek reference.
Space, also known as spacetime or more fully as the spacetime continuum, is the plane of existence home to the known universe.
When a starship reaches the speed of warp 10, it exists at every point on the spacetime continuum at once. (VOY: "Threshold")
The Krenim weapon ship used by Annorax worked by pushing the target outside the spacetime continuum, thus deleting it from history. (VOY: "Year of Hell")
Disruption to the spacetime continuum can have serious repercussions. In 2368, for example, the USS Enterprise-D unknowingly entered a rupture in the space-time continuum, which threw the ship and its crew into a temporal causality loop, experiencing the same time frame over and over. (TNG: "Cause and Effect").
Similar phenomena, such as spatial ruptures or subspace rifts, have been encountered by numerous starships throughout the galaxy.
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[edit] Background
A few Star Trek-related people have been to "outer space," briefly leaving Earth's atmosphere. Astronaut Mae Jemison has flown on a space shuttle. Stephen Hawking participated in a zero-gravity flight. Gene Roddenberry and James Doohan have both had their ashes flown to outer space. A tiny model of the Enterprise has also flown aboard a space shuttle.
