Ticonderoga

From Memory Alpha, the free Star Trek reference.

The Ticonderoga was a 22nd century Earth freighter. In 2154, the Starfleet ship Enterprise received word that the Ticonderoga was missing approximately six hours from Andoria. When Enterprise arrived at the last known coordinates of the Ticonderoga, it was discovered that it had been destroyed by a Romulan drone-ship. All that remained of the Ticonderoga was hull fragments, nacelle casings and several human bodies. (ENT: "The Aenar")

According to Wired magazine, Ticonderoga was named as a subtle nod to the hometown of fan filmmaker James Cawley.